We study rare childhood diseases using medical genetics, genomics, and Drosophila models.
- Understand the underlying mechanisms of Mendelian disease.
- Clinical and genetic aspects of rare human disease phenotypes as insight into human health
- Utilize genomics, metabolomics, and Drosophila models to solve undiagnosed diseases for families.
The long-term goal of the Wangler lab is to improve understanding of the molecular pathogenesis of Mendelian disease by merging clinical observations, genomics, and model organisms. We are pursuing gene discovery efforts using the Drosophila model organism to identify the underlying molecular pathology.
Dr. Wangler is a physician-scientist and pediatrician at the Texas Children’s Hospital and co-director of the Model Organism Screening Center (MOSC) of the Undiagnosed Diseases Network (UDN). The Wangler lab and collaborators make up the Drosophila core of the MOSC.
The Wangler lab has also taken on functional validation cases in Drosophila for the Baylor College of Medicine Center for Precision Medicine.