Research

Congenital Developmental Heart Disease

Master
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Description of the Theme

Content

The CVRI Congenital Developmental Heart Disease Theme researchers conduct a wide spectrum of basic science as well as clinical and translational studies. The Texas Children’s Hospital Heart Center and Baylor College of Medicine drive pediatric cardiovascular disease care through scientific discovery and treatment innovation. Funded efforts include projects pursued as a Core Center for the NHLBI Pediatric Heart Network, other funded clinical research projects, and fundamental basic science projects. The basic research projects investigate molecular and biomechanical regulation of heart and vascular development, the roles of intercellular communication in cardiomyocyte proliferation, genetic pathways involved in cardiac development and regeneration, as well as mechanisms of abnormal cardiovascular development. In these efforts, the researchers take advantage of genetic mouse models and state-of-the-art embryonic imaging and phenotyping resources established at BCM through the NIH-funded Knockout Mouse Production and Phenotyping Project for lethal lines as well as unique new technologies for cardiovascular imaging being developed by the faculty of the Optical Imaging and Vital Microscopy (OIVM) Core and other Advanced Technology Cores. 
 

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Theme Leaders

People
First Name
Irina
Middle Name
V.
Last Name
Larina
Honorific Title
Ph.D.
Professor
First Name
Daniel
Middle Name
James
Last Name
Penny
Honorific Title
M.D., Ph.D., MHA
Professor
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Current Clinical Projects

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Pediatric Heart Network Studies

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Title of Study

Principal Investigator(s)

Multi-Institutional Neurocognitive Discovery Study (Minds) in Adult Congenital Heart Disease (ACHD)

Peter Ermis

Fontan-Associated Liver Disease (FALD)

Daniel Penny

Fontan Udenafil Exercise Longitudinal Assessment Trial and Open Label Extension (FUEL, FUEL OLE)  

Daniel Penny

Perceptions of Participation in a Pediatric Research Study the FUEL and FUEL OLE Trials

Daniel Penny

Minds Imaging Ancillary Study

Peter Ermis

(FORCE) Fontan Outcome Registry Using CMR Examinations

Justin Weigand

Use of Oxandrolone to Promote Growth in Infants with Hypoplastic Left Heart Syndrome: a Phase I/II Pilot Study

Rocky Tsang

Perceptions Oxandrolone Ancillary Study

Rocky Tsang

Dyslipidemia Of Obesity Intervention Trial (DO-IT)

Justin Zachariah

Analgesia And Sedation After CHS nn Down Syndrome

Barbara-Jo Achuff

Team 4 Growth Study 

Rocky Tsang

Long-Term Outcomes after the Multisystem Inflammatory Syndrome in Children

Lara Shekerdemian

Researching Covid to Enhance Recovery

Lara Shekerdemian

Child Down Syndrome

Lisa Noll

Clinical Trial First Prospective Study to Compare Efficacy and Outcomes of Shunt Versus Stent for Neonates with Cyanotic Congenital Heart Disease

Athar Qureshi

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Clinical Research Studies- Federal, Industry, Other

Content

Title of Study

Principal Investigator(s)

Genetic Investigations in Atrial Arrhythmias

Christina Miyake

A Prospective, Randomized, Open Label, Multi-Center Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagonist or LMWH in Pediatric Subjects with Congenital or Acquired Heart Disease Requiring Chronic Anticoagulation or Thromboembolism Prevention

Asra Khan

Fetal Atrial Flutter & Supraventricular Tachycardia (FAST) Therapy Trial

Shaine Morris

Alterra: Multicenter Study of Congenital Pulmonic Valve Dysfunction Studying the Sapien 3 Transcatheter Heart Valve with the Alterra Adaptive Prestent

Gary Stapletion

Evaluation of Contribution of HLA Type and HLA Antibodies in Survival after Pediatric Heart Transplantation

Joseph Spinner

Development of a Risk Calculator to Predict Sudden Cardiac Death in Children with Hypertrophic Cardiomyopathy

Taylor Howard

Rubato (Prospective, Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study Assessing The Efficacy And Safety Of Macitentan in Fontan-Palliated Adult and Adolescent Subjects)

Angeline Opina Gonzalez

Harmony Transcatheter Pulmonary Valve Clinical Study

Athar Qureshi

Multi-Centre, Open-Label, Safety Study of Etripamil Nasal Spray in Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia

Wilson Lam

Building Mobile Technologies to Reduce Disparities in Congenital Heart Disease

Keila Lopez

Development of a Polymeric Percutaneous Pulmonary Valve for use in Young Children

Kwon Soo Chun

Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)

Tam Doan

The Discovery of Novel Genes in Inherited Sudden Arrhythmic Death Syndromes

Christina Miyake

Year 4: Multi-Site Validation Study of the Hlhs Arrest Predictor

Craig Rusin

Improving Adherence to Penicillin Among Children with Rheumatic Heart Disease in Malawi, Africa

Amy Sanyahumbi

Investigating Parasitism-Induced Immune Dysregulation and Susceptibility to Acute Rheumatic Fever in Children

Amy Sanyahumbi

Causal Mechanisms in Adolescent Arterial Stiffness

Justin Zachariah

Evaluating the Effects of Moderate Physical Activity on Health and Well-Being in Adolescents and Young Adults with Marfan Syndrome

Shaine Morris

Multimodal Chest E-Tattoo with Customized IC and Deep Learning Algorithm for Tracking and Predicting Progressive Pneumonia 

Craig Rusin

A Ready-To-Feed, Nutrient-Dense Infant Formula in the Dietary Management of Infants with Growth Failure (GROW-IN)

Rocky Tsang

Advancing Research in Coronary Anomalies through Capacity Building and Community Engagement

Silvana Molossi

Amplatzer Duct Occluder II Additional Sizes (ADO II AS) Clinical Study

Manish Bansa    Gary Stapleton

Development of a Novel Fully Implantable Circulatory Support Device with Dual-Impeller in Single Drive System for Long-Term Use in the Fontan Circulation

Christopher Broda

Collaborative for Longitudinal Aortic Imaging in the Young (CLARITY)

Shaine Morris

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Current Basic Research Projects

Content

Title of Study

Principal Investigator(s)

ID Number

Dynamic regulation of embryonic endothelial cell migration in response to hemodynamic force

Mary Dickinson

R01HD099026 

Mechanisms of Abnormal Diaphragm and Cardiac Development

Daryl Scott

R01HD098458

The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2)

Mary Dickinson

Jason Heaney

UM1HG006348

Biomechanics of Early Mammalian Cardiogenesis

Irina Larina

R01HL120140

Regulation of Hematopoietic Progenitors by de novo DNA Methylation

Peggy Goodell

R01DK092883

Modifiable Drivers of Expansion and Malignant Transformation from Clonal Hematopoiesis

Peggy Goodell

Katherine King

P01CA265748

DNMT3A in Development of Hematologic Malignancies

Peggy Goodell

R01CA183252

Pathogenic mechanisms and therapeutics for the cardiac manifestations of myotonic dystrophy type 1

Thomas Cooper

R01HL147020

Cytoskeletal Control of Yap in Heart Regeneration

James Martin

R01HL169511

Hippo and Wnt Signaling in Cardiac Regeneration

James Martin

R01HL127717

Explore the roles of intercellular communication in cardiomyocyte proliferation and renewal

Liang Xie

R01HL166549

Impact of Infection and Inflammation on Primitive Hematopoiesis

Katherine King

R35HL155672

 

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Research Faculty

Content

Sebastian Acosta, Ph.D., M.S., B.S.

Pediatrics - Cardiology

Iki Adachi, M.D.

Congenital Heart Surgery

Dean Andropoulos, M.D.  

Brain protection for infant cardiac surgery

Deidra Ansah, M.D.

Pediatrics - Cardiology

Ayse Arikan, M.D.

Pediatrics - Critical Care Medicine

Natahsa Afonso, M.D., MPH

Pediatric - Critical Care Medicine

Rahul Baijal, M.D.

Pediatrics - Anesthesiology

Manish Bansal, M.D.

Pediatrics - Cardiology

Ziyad Binsalamah M.B., B.S., M.SC., M.SC.

Congenital Heart Service

Ravi Birla PH.D., M.B.A.

Congenital Heart Surgery

Christopher Broda, M.D.

Pediatrics - Cardiologys

Christopher Caldarone, M.D.

Congenital Heart Surgery

Lisa Caplan M.D., B.S.

Pediatrics - Anesthesiology

Arvind Chandrakantan, M.D.

Pediatrics - Anesthesiology

Swati Choudhry, M.D.

Pediatrics - Cardiology

Thomas Cooper, M.D.

Pathology & Immunology; Alternative splicing in cardiac 
development and disease

Susan Denfield, M.D.

Pediatrics - Cardiology

Mary Dickinson, Ph.D.

Integrative Physiology; Cardiovascular developmental biology

Tam Doan, M.D.

Pediatrics - Cardiology

William Dreyer, M.D.

Pediatrics - Cardiology; New heart failure therapies, management 
of HLA sensitized patients before/after transplant

Ronald Easley, M.D.

Pediatrics - Anesthesiology, New methods for monitoring and 
management of children with heart disease

Peter Ermis, M.D.

Pediatrics - Cardiology

Saul Flores, M.D.

Congenital Heart Service

Yuxin Fan, M.D., Ph.D.

Pediatrics - Cardiology; Diagnostic tests for acquired and 
genetic cardiac diseases, viral myocarditis

Peggy Goodell, M.D.

Molecular & Cellular Biology; Hematopoietic stem cells, 
epigenetic modifications

Srinath Gowda, M.B.,B.S.

Pediatrics - Cardiology

Jeffrey Heinle, M.D.

Congenital Heart Surgery

Edward Hickey, M.D.

Congenital Heart Surgery

Taylor Howard, M.D.

Pediatrics - Cardiology

Chih-Wei Logan Hsu, Ph.D., M.S.

Integrative Physiology; Large scale cardiovascular mouse 
embryo phenotyping, imaging technology development for 
cardiovascular studies

Timothy Humlicek, Pharm.D.

Pediatrics - Cardiology

 Michiaki Imamura, M.D., Ph.D.

Congenital Heart Surgery

 Asra Khan, M.D.

Pediatrics - Cardiology

Jeffrey Kim, M.D.

Pediatrics - Cardiology

 Katherine King, M.D.

Pediatrics - Infectious Disease; Hematopoietic stem cell biology

Wilson Lam, M.D.

Pediatric Cardiology

Irina Larina, Ph.D

Integrative Physiology; Biomechanics of early cardiogenesis, 
technology development in cardiovascular imaging

 Christian Lilje, M.D.

Pediatrics - Cardiology

Aimee Liou, B.S.

Pediatrics - Cardiology

Chyongjy Liu D.O., M.B.A.

Pediatrics - Anesthesiology

Keila Lopez, M.D., M.P.H.

Pediatrics - Cardiology

James Martin, M.D.

Integrative Physiology; Hippo, Wnt, Bmp signaling in 
development, regeneration, heart disease

Christina Miyake, MS, M.D.

Pediatrics - Cardiology; Inherited cardiac arrhythmia syndromes

Silvana Molossi, M.D., PH.D.

Pediatric Cardiology

Shaine Morris, M.D., MHP

Pediatrics - Cardiology; Advanced imaging techniques for 
genetically-triggered aortopathies

 Emad Mossad B. M.B., B.CH., B.S.

Pediatrics - Anesthesiology; Neuromonitoring during 
repair of congenital heart disease

Angeline Opina Gonzalez, M.D.

Pediatrics - Cardiology

 Jain Parag, M.B., B.S.

Pediatrics - Critical Care Medicine

Daniel Penny, M.D., PH.D., M.H.A.

Pediatrics - Cardiology

 Tam Dan (Tina) Pham, M.D.

Pediatrics - Cardiology

 Ricardo Pignatelli, M.D.

Pediatrics - Cardiology; Echocardiography, 
pediatric cardiomyopathy, ultrasound-targeted microbubbles, 
Duchenne muscular dystrophy

Jack Price,M.D.

Pediatrics - Cardiology

Athar Qureshi, M.B., B.S.

Pediatrics - Cardiology

Ashraf Resheidat, M.D.

Pediatrics - Anesthesiology

Alan Riley,M.D.

Pediatrics - Cardiology

Ross Poche, Ph.D., B.S.

Integrative Physiology; Cardiac development

Elizabeth Rossmann Beel, M.D., M.P.H., B.A.

Pediatrics - Anesthesiology

 Craig Rusin, Ph.D.

Pediatrics - Cardiology; Physiological signal 
processing and algorithm development

Shagun Sachdeva, M.D.

Pediatrics - Cardiology

Katherine Salciccioli, M.D.

Pediatrics - Cardiology

Aura Sanchez Mejia, M.D.

Pediatrics - Cardiology

Amy Sanyahumbi, M.D.

Pediatrics - Cardiology

Tobias Schlingmann, M.D., Ph.D.

Pediatrics - Cardiology

Daryl Scott, M.D., Ph.D.

Human & Molecular Genetics; Genetics of congenital 
diaphragmatic hernia, esophageal atresia, cardiomyopathies

Sara Sexson Tejtel, M.D., PH.D., M.P.H.

Pediatrics - Cardiology

Shreya Sheth, M.D.

Pediatrics - Cardiology

Joseph Spinner, M.D.

Pediatrics - Cardiology

Gary Stapleton, M.D.

Pediatrics - Cardiology

Sebastian Tume, M.D.

Pediatrics - Critical Care Medicine

Venée Tubman, M.D.

Pediatrics - Hematology/Oncology; Sickle cell disease 
and B cell deficiency

Hari Tunuguntla, M.D.

Pediatrics: Cardiology

Santiago Valdes, M.D.

Pediatrics: Cardiology

Jesus Vallejo, M.D.

Pediatrics Cardiology; TLR3/TLR4 in acute myocarditis, 
signal transduction pathways

David Vener, M.D.

Pediatrics - Anesthesiology

Giles Vick, M.D., Ph.D.

Pediatrics - Cardiology

Lalita Wadhwa, Ph.D.

Congenital Heart Surgery

Melissa Webb, M.D.

Pediatrics - Cardiology

Justin Weigand, M.D.

Pediatrics - Cardiology

James Wilkinson, M.D.

Pediatrics - Cardiology

Liang Xie, Ph.D.

Medicine; Cardiogenesis and cardiomyocyte renewal

Betul Yilmaz, M.D.

Pediatrics - Cardiology

Justin Zachariah, M.D.

Pediatrics - Cardiology