Department of Medicine

Hematology and Oncology Clinical Research Faculty


The following are research studies conducted by individual investigators.

Malcolm K. Brenner, M.D., Ph.D.

  • Activity of lymphotactin in childhood malignancy
  • Treatment of Hodgkin's disease with gene marked cytotoxic T lymphocytes
  • Cytotoxic T Cell transfer for therapy of EBV lymphoma
  • Effects of CD45 monoclonal antibodies on normal and malignant hemopoiesis
  • Therapeutic effects of CD 40L in acute lymphoblastic leukemia

George Carrum, M.D.

  • Pilot study of allogeneic stem cell transplantation with submyeloablative conditioning therapy for hematological diseases
  • High-dose chemotherapy for Stage II/III breast cancer without stem cell rescue

Helen E. Heslop, M.D., M.B.,Ch.B.

  • Immunotherapy with EBV-specific CTLs for EBV-positive Hodgkin's disease
  • Immunotherapy with EBV-specific CTLs for nasopharyngeal cancer
  • Immunotherapy with EBV-specific CTLs for PTLD
  • Augmenting antiviral and anti-tumor immunity after hemopoietic stem cell transplants

Clinical research nurses for Dr. Heslop:
Goley Richardson, (713) 441-1038
Susan Feliciano, (713) 394-6942


Martha Pritchett Mims, M.D., Ph.D.

Investigator on multiple cancer clinical trials at the Michael E. DeBakey VA Medical Center and at Ben Taub Hospital. View a list of currently open cancer-related clinical trials.

For more information on studies done at the VA, contact research associates Teresa Joe at (713) 791-1414, ext. 25225, or Tiffany Perry at (713) 791-1414, ext. 24667.


Nicholas Mitsiades, M.D.

  • Exploring and targeting the mechanisms involved in hormonal regulation of cancer (in particular of prostate cancer by androgen, and of breast cancer by estrogen)
  • Identifying clinically applicable inhibitors of the expression and/or function of steroid receptor coactivators
  • Investigating the mechanisms involved in the anticancer activity of the diabetes drug metformin and the lipid-lowering drugs HMG-CoA reductase inhibitors (statins)
  • Targeting the signaling pathways triggered by somatic mutations in the G protein α subunits Gαq and Gα11 (encoded by the genes GNAQ and GNA11, respectively) in uveal melanomas
  • Exploring novel therapies for thyroid cancer

Benjamin Leon Musher, M.D.

  • Biology and genetics of colorectal cancer, particularly young-onset colorectal cancer
  • Disparities in access to cancer care by race/ethnicity and socioeconomic status
  • Novel treatment strategies for pancreatic cancer

C. Kent Osborne, M.D.

  • Biology, diagnosis, prognostic factors, prevention and treatment of breast cancer

Gustavo A. Rivero, M.D.

  • Malignant hematology diseases, including leukemia, lymphoma and myeloma