Cardiac regeneration gene therapy involves the use of specific genes to stimulate the regeneration of damaged heart tissue. The Laboratory for Cardiac Regeneration is developing several new gene therapies to regenerate the heart based on direct cardiac reprogramming and induction of the cell cycle in cardiomyocytes. We are conducting extensive research to further understand and optimize these different modalities for cardiac regeneration gene therapy. Our animal studies have shown promising results, with improved cardiac function and tissue regeneration observed after gene delivery. We are currently exploring different delivery methods, including viral vectors and non-viral methods, to safely and efficiently introduce the therapeutic genes into the heart. We are also investigating the most effective combination of genes and the optimal timing for gene delivery. Furthermore, studies are underway to better comprehend the underlying molecular mechanisms involved in the regenerative process, with the goal of developing targeted and personalized therapies for patients with heart disease.