Margaret Ann Goldstein, Ph.D.
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Margaret Ann Goldstein, Ph.D.
Professor Emeritus
Positions
- Professor Emeritus
-
Medicine-Cardiovascular Sciences
Baylor College of Medicine
Houston, TX US
- Professor Emeritus
-
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas United States
- Professor of Medicine
-
Medicine
Cardiovascular Sciences
Baylor College of Medicine
Houston, Texas United States
- Life Member of Clare Hall
-
Center for Advanced Studies
History and Philosophy of Science
Cambridge University
Cambridge, United Kingdom
Education
- PhD from Rice University
- 05/1969 - Houston, Texas United States
- Cell Biology
- BA from Rice University
- 05/1965 - Houston, Texas United States
- Biology
- Fellowship at University of Cambridge Clare Hall
- 01/2002 - Cambridge, United Kingdom
- Department of History and Philosophy of Science
Honors & Awards
- Lifetime Achievement Award
- Albert Nelson Marquis (01/2017)
- Research Career Development Award
- National Institutes of Health (01/1975)
- Established Investigator
- American Heart Association (01/1975)
- Outstanding Houston Woman in Science and Technology
- YWCA (01/1990)
- Woman on the Move Award
- Texas Executive Women (01/2002)
- Citation
- Who's Who in America
Professional Statement
I have been a member of the faculty of Baylor College of Medicine since 1970. With funding from the National Heart Lung and Blood Institute (NHLBI), the American Heart Association and the Muscular Dystrophy Association I have studied cellular ultrastructure. In 1980 I brought the first 200kv Electron Microscope to Texas and then directed a research program in cardiovascular sciences for 15 years. My teaching has been in anatomy, medicine, and cell biology with an emphasis on the cardiovascular system, heart and skeletal muscle, and imaging in medicine. I have served on BCM committees—admissions, accreditation, equal opportunity, faculty research support and as an elected faculty representative to the Executive Faculty.A recent major research accomplishment has been the first 3-D reconstruction of the Z-band lattice in mammalian skeletal muscle. This and other related papers on the role of the Z band in heart and skeletal muscle continue to be of interest because of the remodeling of muscle in response to microgravity.
From 1986 to 1996 I was a member of the NASA-COSMOS program, one of four NASA scientists to work in Moscow in 1990, and in 1994, invited speaker on cardiovascular function and disease in the Workshop on Research in the Microgravity Environment for NASA-NHLBI. My papers on muscle structure and function in microgravity and hypergravity have raised some interesting questions that are still being answered.
In the mid ‘90’s as an Executive Board Member of the Council of Scientific Society Presidents, I was part of a think tank on Science and Medicine in 25 years and in 50 years. Then for the American Heart Association I was part of a leadership task force for the role of AHA in the 21st century world of fast paced technological change. These experiences really made me a futurist. I reviewed the major themes of my past research: imaging, the space program and cardiovascular sciences, and I established a new direction for my future work.
When I was invited to apply as a Fellow at the University of Cambridge, it was easy to write a one page proposal entitled Vision and Symbolic Language, and I introduced myself as a Quantum Biologist. I realized that my tools were now at the nanometer level and the frontier was the world of electrons and photons. My quest, to answer how do we see with photons (light entering the eye) and why is seeing so important, is now a 17 year journey. My continuing research in heart and muscle is vital to our space program and the future welfare of all of us.
Websites
Professional Development
- The Properties of Electrons in Relation to Human Consciousness
- Seminar (Presenter, 2011)
- Sponsor: University of Cambridge Clare Hall
- Human Vision and Expanding Consciousness
- Seminar (Presenter, 2009)
- Sponsor: University of Cambridge Clare Hall
- A 21st Century Scientist Looks at Sir Isaac Newton
- Seminar (Presenter, 2009)
- Sponsor: University of Cambridge, Department of History and Philosophy of Science
Selected Publications
- Goldstein, MA "Human Vision, Cosmic Forces in the 2st Century Scientist." Microsc Microanal. 2017;(Abstract)
- Goldstein, MA and Schroeter, JP "Ultrastructure of the Heart. In: Handbook of Physiology Volume 1: The Heart." Section 2: The Cardiovascular System. 2002;Ed. Page, E., Fozzard, H.A. and Solaro, R.J.(Oxford University Press):3-74; ISBN-10: 0195098862.
- Goldstein, MA, Cheng, J and Schroeter, JP "The effects of increased gravity and microgravity on cardiac morphology." Aviat Space Env Med. 1998;69:6-11. Pubmed PMID: 10776447
- Schroeter, JP, Bretaudier, J-P, Sass, RL and Goldstein, MA "The three-dimensional structure of the Z band in a normal mammalian skeletal muscle." J Cell Biol. 1996;133(3):571-583. Pubmed PMID: 8636232
- Goldstein MA, Edwards, RJ and Schroeter, JP "Cardiac morphology after conditions of microgravity during Cosmos 2044." J Applied Physiol. 1992;73:94S-100S. Pubmed PMID: 1526957
- Goldstein, MA and Entman, ML "Microtubules in mammalian heart muscle." J Cell Biol. 1979;80:183-195. Pubmed PMID: 422649
Memberships
- Sigma Xi
- Member
- American Association for Advancement of Science
- Member
- American Society for Cell Biology
- Member
- Microscopy Society of America
- Member
- Microscopy Society of Texas
- Member
- Biophysical Society
- Member
- American Heart Association
- Member
- Association of Women in Science
- Member
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