Antibody-Based Proteomics Publications

Wang X, Shi Z, Lu HY, Kim JJ, Bu W, Villalobos JA, Perera DN, Jung SY, Wang T, Grimm SL, Taylor BC, Rajapakshe K, Park H, Wulfkuhle J, Young NL, Li Y, Coarfa C, Edwards DP, Huang S. High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array. J Proteomics. 2022 Jun 30;262:104596. doi: 10.1016/j.jprot.2022.104596. Epub 2022 Apr 27. PMID: 35489683.

Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu HY, Wang X, Christensen KR, Mo Q, Edwards DP, Huang S. Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration. J Biomol Tech. 2021 Apr;32(1):15-29. doi: 10.7171/jbt.21-3202-001. PMID: 34025221; PMCID: PMC8121080.

Bado IL, Zhang W, Hu J, Xu Z, Wang H, Sarkar P, Li L, Wan YW, Liu J, Wu W, Lo HC, Kim IS, Singh S, Janghorban M, Muscarella AM, Goldstein A, Singh P, Jeong HH, Liu C, Schiff R, Huang S, Ellis MJ, Gaber MW, Gugala Z, Liu Z, Zhang XH. The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells. Dev Cell. 2021 Apr 19;56(8):1100-1117.e9. doi: 10.1016/j.devcel.2021.03.008. PMID: 33878299; PMCID: PMC8062036.

Napierala JS, Rajapakshe K, Clark A, Chen YY, Huang S, Mesaros C, Xu P, Blair IA, Hauser LA, Farmer J, Lynch DR, Edwards DP, Coarfa C, Napierala M. Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia. Mol Cell Proteomics. 2021 May 13;20:100094. doi: 10.1016/j.mcpro.2021.100094. Epub ahead of print. PMID: 33991687.

Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, Coarfa C,

Zhang XH, Liu Q, Lin X, Li Y. A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res. 2021 Jun 7:canres.1112.2021. doi: 10.1158/0008-5472.CAN-21-1112. Epub ahead of print. PMID: 34099494.

Hsin-Yi Lu, Jian Xiong, Dimuthu Nuwan Perera, Kimal Rajapakshe, Xuan Wang, Fuli Jia, Myra Costello, Kimberly Holloway, Danli Wu, Carlos Ramos, Cristian Coarfa, Dean P. Edwards, Michael X. Zhu, Shixia Huang. High Throughput Evaluation of Metabolic Activities Using Reverse Phase Protein Array (RPPA). In: Tong, Q., ed. Neuronal Signaling in Neuron Signaling in Metabolic Regulation, 1st Ed. 2021, p. 293, CRC Press, Boca Raton and London

Hebert KA, Jaramillo S, Yu W, Wang M, Veeramachaneni R, Sandulache VC, Sikora AG, Bonnen MD, Annapragada AV, Corry D, Kheradmand F, Pandita RK, Ludwig MS, Pandita TK, Huang S, Coarfa C, Grimm SL, Perera D, Miles G, Ghebre YT. Esomeprazole enhances the effect of ionizing radiation to improve tumor control. Oncotarget. 2021 Jul 6;12(14):1339-1353. doi: 10.18632/oncotarget.28008. PMID: 34262645; PMCID: PMC8274720.

Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Berman De Ruiz K, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. Inhibition of GATA2 in prostate cancer by a clinically available small molecule. Endocr Relat Cancer. 2021 Nov 24;29(1):15-31. doi: 10.1530/ERC-21-0085. PMID: 34636746

Corn PG, Zhang M, Nogueras-Gonzalez GM, Xiao L, Zurita AJ, Subudhi SK, Tu SM, Aparicio AM, Coarfa C, Rajapakshe K, Huang S, Navone NM, Lin SH, Wang G,Ramachandran S, Titus MA, Panaretakis T, Gallick GE, Efstathiou E, Troncoso P,Logothetis C. A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer. Clin Cancer Res. 2020 Mar 1;26(5):990-999. doi: 10.1158/1078-0432.CCR-19-2389. Epub 2020 Jan 15. PubMed PMID: 31941830.

Zhang T, Choi S, Zhang T, Chen Z, Chi Y, Huang S, Xiang JZ, Du YN. miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. Am J Pathol. 2020 Mar;190(3):689-701. doi: 10.1016/j.ajpath.2019.11.007. Epub 2020 Jan 14. PubMed PMID: 31953039; PubMed Central PMCID: PMC7074368.

Sharma M, Khong H, Fa'ak F, Bentebibel SE, Janssen LME, Chesson BC,

Creasy CA, Forget MA, Kahn LMS, Pazdrak B, Karki B, Hailemichael Y, Singh M, Vianden C, Vennam S, Bharadwaj U, Tweardy DJ, Haymaker C, Bernatchez C, Huang S, Rajapakshe K, Coarfa C, Hurwitz ME, Sznol M, Hwu P, Hoch U, Addepalli M, Charych DH, Zalevsky J, Diab A, Overwijk WW. Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun. 2020 Jan 31;11(1):661. doi: 10.1038/s41467-020-14471-1. PMID: 32005826; PMCID: PMC6994577. 

Elsarraj HS, Hong Y, Limback D, Zhao R, Berger J, Bishop SC, Sabbagh A, Oppenheimer L, Harper HE, Tsimelzon A, Huang S, Hilsenbeck SG, Edwards DP, Fontes J, Fan F, Madan R, Fangman B, Ellis A, Tawfik O, Persons DL, Fields T, Godwin AK, Hagan CR, Swenson-Fields K, Coarfa C, Thompson J, Behbod F. BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression. NPJ Breast Cancer. 2020 Apr 24;6:12. doi: 10.1038/s41523-020-0157-z. PMID: 32352029; PMCID: PMC7181646.

Subramonian D, Phanhthilath N, Rinehardt H, Flynn S, Huo Y, Zhang J, Messer K, Mo Q, Huang S, Lesperance J, Zage PE. Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways. Br J Cancer. 2020 Aug;123(4):568-579. doi: 10.1038/s41416-020-0905-8. Epub 2020 May 27. PMID: 32457362; PMCID: PMC7434894.

Xue L, Chen F, Yue F, Camacho L, Kothapalli S, Wei G, Huang S, Mo Q, Ma F, Li Y, Jiralerspong S. Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer. Breast Cancer Res Treat. 2021 Jan;185(1):73-84. doi: 10.1007/s10549-020-05927-5. Epub 2020 Sep 17. PMID: 32940848; PMCID: PMC7855212.

Guo Z, Primeau T, Luo J, Zhang C, Sun H, Hoog J, Gao F, Huang S, Edwards DP, Davies SR, Aft R, Ding L, Ellis MJ, Li S, Ma CX. Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models. Cancers (Basel). 2020 Dec 21;12(12):3857. doi: 10.3390/cancers12123857. PMID: 33371187; PMCID: PMC7765949.

Shneider BL, Cortes-Santiago N, Schady DA, Krishnamoorthy S, Thevananther S, Rajapakshe K, Perera D, Huang S, Coarfa C. Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer. Am J Physiol Gastrointest Liver Physiol. 2021 Mar 1;320(3):G366-G379. doi: 10.1152/ajpgi.00065.2020. Epub 2021 Jan 20. PMID: 33470189.
 

Bu W, Liu Z, Jiang W, Nagi C, Huang S, Edwards DP, Jo E, Mo Q, Creighton CJ, Hilsenbeck SG, Leavitt AD, Lewis MT, Wong STC, Li Y. Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes. Cancer Res. 2019 Jan 1;79(1):61-71.2018 Nov. CAN-18-1087. [Epub ahead of print] PubMed PMID: 30401712.

Finnerty BM, Moore M, Verma A, Aronova A, Huang S, Edwards DP, Chen Z,    Seandel M, Scognamiglio T, Du N, Elemento O, Zarnegar R, Min IM, Fahey TJ. UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors. Endocr Relat Cancer. 2019 Jan 1. pii: ERC-18-0507.R1. doi: 10.1530/ERC-18-0507. [Epub ahead of print] PubMed PMID: 30689542.

Yao M, Fang W, Smart C, Hu Q, Huang S, Alvarez N, Fields P, Cheng N. CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells Through SRC and PKC Activation. Mol Cancer Res. 2019 Feb;17(2):604-617. PMID: 30446625; PubMed Central PMCID: PMC6359961.

Sethunath V, Hu H, De Angelis C, Veeraraghavan J, Qin L, Wang N, Simon LM,Wang T, Fu X, Nardone A, Pereira R, Nanda S, Griffith OL, Tsimelzon A, Shaw C, Chamness GC, Reis-Filho JS, Weigelt B, Heiser LM, Hilsenbeck SG, Huang S, Rimawi MF, Gray JW, Osborne CK, Schiff R. Targeting the

Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer. Mol Cancer Res. 2019 Nov;17(11):2318-2330. doi: 10.1158/1541-7786.MCR-19-0756. Epub 2019 Aug 16. PubMed PMID: 31420371; PubMed Central PMCID: PMC6825570.

Lee YJ, Ho SR, Graves JD, Xiao Y, Huang S, Lin WC. CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019 Dec 4;21(1):134. PubMed PMID: 31801577.

Fu X, Pereira R, De Angelis C, Veeraraghavan J, Nanda S, Qin L, Cataldo ML, Feng Q, Jeselsohn R, Nardone A, Huang S, Edward DP, O'Malley BW, Brown M, Osborne CK, Schiff R. FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer Proc Natl Acad Sci U S A. 2019 Dec 11. pii: 201911584. doi: 10.1073/pnas.1911584116. [Epub ahead of print]. PMID: 31826955