About the Lab
The Wang lab is interested in brain estrogenic actions in the regulation of energy and glucose balance under different physiological conditions, including:
- Sex differences in response to nutritional challenges
- Female body weight and feeding controls in menopause
- Pregnancy and lactation
We use Cre-loxP/Flp-frt or CRISPR strategy to manipulate genes of interest and use chemogenetics/optogenetics strategy to manipulate neuronal activities in specific neuron populations in specific time window in adult mice. In combination with photometry, electrophysiology and neurotracing approaches, we explore the functions of hypothalamic neurons in energy and glucose balance in female mice at different life stage and nutrition conditions.