Hadsell Lab Publications


In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.
Hadsell DL, Hadsell LA, Rijnkels M, Carcamo-Bahena Y, Wei J, Williamson P, Grusak MA.
Mamm Genome. 2018 Oct;29(9-10):632-655. doi: 10.1007/s00335-018-9762-7. Epub 2018 Aug 2.
PMID: 30073618

In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci.
Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TC.
Mamm Genome. 2015 Feb;26(1-2):57-79. doi: 10.1007/s00335-014-9551-x. Epub 2015 Jan 1.
PMID: 25552398 Free PMC article.

In silico QTL mapping of maternal nurturing ability with the mouse diversity panel.
Hadsell DL, Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P.
Physiol Genomics. 2012 Aug 17;44(16):787-98. doi: 10.1152/physiolgenomics.00159.2011. Epub 2012 Jul 3.
PMID: 22759921 Free PMC article.

Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans.
Mohammad MA, Hadsell DL, Haymond MW.Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E365-76. doi: 10.1152/ajpendo.00175.2012. Epub 2012 May 29.PMID: 22649065 Free PMC article.

Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women.
Maningat PD, Sen P, Rijnkels M, Hadsell DL, Bray MS, Haymond MW.
Physiol Genomics. 2011 Apr 27;43(8):381-91. doi: 10.1152/physiolgenomics.00079.2010. Epub 2011 Jan 4.
PMID: 21205870 Free PMC article.

Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle.
Hadsell DL, Olea W, Wei J, Fiorotto ML, Matsunami RK, Engler DA, Collier RJ.
Physiol Genomics. 2011 Mar 29;43(6):271-85. doi: 10.1152/physiolgenomics.00133.2010. Epub 2010 Dec 28.
PMID: 21189371

Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression.
Hadsell DL, Parlow AF, Torres D, George J, Olea W.
J Endocrinol. 2008 Jul;198(1):61-70. doi: 10.1677/JOE-07-0556.
PMID: 18577570

Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.
Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV.
J Endocrinol. 2007 Aug;194(2):327-36. doi: 10.1677/JOE-07-0160.
PMID: 17641282

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.
Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV.
Cell Cycle. 2007 Mar 15;6(6):705-13. doi: 10.4161/cc.6.6.4035. Epub 2007 Mar 20.
PMID: 17374994 Review.

The declining phase of lactation: peripheral or central, programmed or pathological?
Hadsell D, George J, Torres D.
J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):59-70. doi: 10.1007/s10911-007-9038-4.
PMID: 17286209 Review.

Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging.
Hadsell DL, Torres D, George J, Capuco AV, Ellis SE, Fiorotto ML.
Exp Gerontol. 2006 Mar;41(3):271-81. doi: 10.1016/j.exger.2005.12.005. Epub 2006 Jan 25.
PMID: 16442254

Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome.
Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW.
Physiol Genomics. 2009 Mar 3;37(1):12-22. doi: 10.1152/physiolgenomics.90341.2008. Epub 2008 Nov 18.
PMID: 19018045 Free PMC article.

Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation.
Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML.
Biol Reprod. 2005 Dec;73(6):1116-25. doi: 10.1095/biolreprod.105.043992. Epub 2005 Aug 3.
PMID: 16079306

The insulin-like growth factor system in normal mammary gland function.
Hadsell DL.
Breast Dis. 2003;17:3-14. doi: 10.3233/bd-2003-17102.
PMID: 15687673

Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G.
Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M.
Mol Endocrinol. 2003 Nov;17(11):2251-67. doi: 10.1210/me.2002-0031. Epub 2003 Aug 7.
PMID: 12907752

Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds.
Bonnette SG, Hadsell DL.
Endocrinology. 2001 Nov;142(11):4937-45. doi: 10.1210/endo.142.11.8500.
PMID: 11606462

Inability of overexpressed des(1-3)human insulin-like growth factor I (IGF-I) to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules.
Hadsell DL, Alexeenko T, Klimentidis Y, Torres D, Lee AV.
Endocrinology. 2001 Apr;142(4):1479-88. doi: 10.1210/endo.142.4.8087.
PMID: 11250928

Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis.
Hadsell DL, Murphy KL, Bonnette SG, Reece N, Laucirica R, Rosen JM.
Oncogene. 2000 Feb 17;19(7):889-98. doi: 10.1038/sj.onc.1203386.
PMID: 10702797

Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups.
Burrin DG, Fiorotto ML, Hadsell DL.
J Nutr. 1999 Jan;129(1):51-6. doi: 10.1093/jn/129.1.51.
PMID: 9915875

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.
Hadsell DL, Greenberg NM, Fligger JM, Baumrucker CR, Rosen JM.
Endocrinology. 1996 Jan;137(1):321-30. doi: 10.1210/endo.137.1.8536631.
PMID: 8536631

Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL.
Endocrinology. 2003 Jun;144(6):2683-94. doi: 10.1210/en.2002-221103.
PMID: 12746333