The MMRU CLAMS unit can house up to 76 mice at a time. This highly versatile system is capable of monitoring/controlling the following parameters, in virtually any permutation.
Automated Food Access Control
The food access control system provides an automated means to control availability of food to the mouse. A computer-controlled pneumatic arm opens and closes the anti-foraging gate, depending upon time of day and/or mass of food consumed. A hinged food guard prevents harm to the mouse if it is feeding at the time at which the anti-foraging gate closes. Food access is accomplished by defining four parameters: Time On (tON), Time Off (tOFF), Duration (DUR; length of food access in hours), and Limit (mass of food consumed in grams). Examples of strategies for feeding regimes can be seen in the graphs. The graphs illustrate control of food access dependent on Weight (A), Time (B, C), or both (D). Examples given for wild-type (control) versus ob/ob mice.
This system enables pair-feeding and meal-feeding studies to be performed with a high level of reliability, precision, and accuracy. The system can be programmed so that mice within an experiment are provided access to specific amounts of food or, in the case of pair-feeding, an amount of food equal to that consumed by a specified "master" mouse or group of mice. In addition to being highly time efficient, this pair-feeding approach provides the pair-fed group with its food at the same time as the “master” group. This avoids the one-day delay between groups that occurs with the traditional manual approach to pair-feeding, and also any effects of time of day that food is eaten.
- System capacity for this parameter: 64 mice
- Maximum housing duration within these cages: 3 months (48 cages)
- Equilibration period recommendation: 2 to 3 days
- Weight range: 10 to 70 g