The majority of ovarian and uterine cancers are sporadic, or happen by chance, however, approximately 5-10% of cancers are caused by an underlying hereditary predisposition. Individuals with a hereditary predisposition for cancer have a genetic change (mutation) that leads to increased risks for specific cancers in them and their family members. This is called a hereditary cancer syndrome.
People with hereditary cancer syndromes benefit from increased cancer screening, as well as prevention options.
You should consider genetic testing if you have:
- Personal or family history of:
- Ovarian cancer
- Endometrial cancer or colon cancer diagnosed younger than 50 years old
- Personal history of multiple cancers (ovarian, endometrial, colon, pancreas, breast, kidney)
- Family history of a known genetic mutation associated with an increased risk for uterine or ovarian cancer such as Lynch syndrome, Peutz-Jeghers syndrome, Cowden (PTEN Hamartoma tumor syndrome) or Hereditary Breast and Ovarian Cancer syndrome
- Multiple family members with cancer(s) of the endometrium, colon, ovaries, pancreas, stomach, biliary tract or urinary system