Grant Title: Interaction of mesenchymal and myeloid fibroblasts in inflammatory-based fibrosis in the aging heart [Cieslik and Entman}
Funding Agency: NIH – National Institutes of Health
Description: The overall goals are to examine cellular and molecular interactions between fibroblasts of two developmental origins (mesenchymal and myeloid) and potential rescue approaches to reduce diastolic dysfunction and cardiac fibrosis in the aging heart.
Grant Title: Molecular mechanisms of dysfunction in the aging heart [Entman}
Funding Agency: Hankamer Foundation
Description: The major goal of this project is to utilize the technology of the genetically altered mouse to evaluate factors that may result in cardiac dysfunction in the infarct aging heart and identify potential remedial approaches.