Grant Title: Role of vimentin in thrombosis and stroke [Cruz]
Funding Agency: NIH – National Institutes of Health
Description: The goal of this grant is to define the novel interaction between von Willebrand factor (VWF) and vimentin expressed on the surface of platelets and endothelial cells, and then examine the potential to capitalize on this novel interaction for the treatment of thrombosis and stroke
Grant Title: Microvascular thrombosis in systemic inflammation [Cruz and Vijayan]]
Funding Agency: NIH – National Institutes of Health
Description: The goal of this project is to use human septic plasma and bacteria-induced systemic inflammation model in pigs and investigate the potential mechanistic role for plasma vimentin in coagulopathy and in promoting pro-inflammatory signaling.
Grant Title: Collaborative research training in thrombosis and inflammation [Cruz and Rumbaut]
Funding Agency: NIH – National Institutes of Health
Description: The goal of this T32 program is to prepare postdoctoral trainees for collaborative research careers in two inter-related topics: Thrombosis and Inflammation. In addition to training physician-scientists in biomedical research, PhD scientists will be trained in translational medicine offering a direct interaction with patients.
Grant Title: Von Willebrand factor in traumatic brain injury and associated coagulopathy (Subcontract) [Cruz]
Funding Agency: NIH – National Institutes of Health
Description: The main goals of the grant are to 1) Target VWF hyper-adhesive activity for TBI-IC therapeutics: 2) Conduct a cohort study of TBI patients to associate VWF hyper-adhesive activity with coagulopathy.
Grant Title: American Heart Association: PP2B modulates RhoA activation and platelet function by targeting RhoGDI [Vijayan]
Funding Agency: AHA – American Heart Association
Description: The goal of this proposal is to investigate the mechanisms that underpin PP2B regulated RhoA activation and platelet function.