Theme Leaders
Current Clinical Projects
A focus of our clinical research this past year has been participation in the NHLBI Pediatric Heart Network (Penny, Andropoulos, Shekerdemian - PIs), which include the following multi-center studies:
|
Title of Study |
Principal Investigator(s) |
ID Number |
|---|---|---|
|
A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics |
Dean Andropoulos |
NA |
|
Collaborative Learning Study of Perioperative Care of Infants with Congenital Heart Disease |
Lara Shekerdemian |
NA |
|
Residual Lesion Score Study |
Carlos Mery |
NA |
|
Pediatric Echocardiography Z-Score and ECG Study |
Ricardo Pignatelli |
NA |
|
Real-Time Predictive Physiological Monitoring for Improving Patient Outcomes After Stage I Palliation |
Craig Rusin |
NA |
|
Building an E-health Platform to Improve Adolescent Transition and Transfer of Care |
Keila Lopez |
NA |
|
Fontan Growth Study |
Tom Seery |
NA |
|
Off-Label Use of the Melody Valve |
Athar Qureshi |
NA |
A few of our non-PHN related research activities include the following:
|
Title of Study |
Principal Investigator(s) |
ID Number |
|---|---|---|
|
A Biomarker to Predict Cardiovascular Events in Patients with Aortic Dilation |
Shaine Morris |
R21HL121630 |
|
Maternal Hyperoxygenation in Fetal Left Heart Hypoplasia |
Judith Becker |
NA |
|
A Standardization of a Novel Method to Assess Fetal Cardiac Function: Myocardial Deformation |
Shiraz Maskatia |
NA |
|
Postzygotic Cardiac Somatic Mutations and the Knudson Model - A Primary Role in the Etiology of Congenital Heart Disease |
Wesley Vick |
NA |
Current Basic Research Projects
|
Title of Study |
Principal Investigator(s) |
ID Number |
|---|---|---|
|
Phenotyping Embryonic Mammalian Heart Function Using OCT |
Mary Dickinson |
R01HL095586 |
|
Retinoid-Related Genes in Diaphragm and Cardiac Development |
Daryl Scott |
R01HD064667 |
|
Fabrication, Perfusion and Imaging of Pre-Vascularized Hydrogel Tissue Scaffolds |
Mary Dickinson |
R01HL097520 |
|
Consortium for Broad Based Disease Phenotyping of Knockout Mice |
Art Beaudet |
U54HG006348 |
|
Consortium for Broad Based Disease Phenotyping of Knockout Mice -- Embryonic Lethal Analysis Supplement |
Art Beaudet |
U54HG006348-S1 |
|
Biomechanics of Early Mammalian Cardiogenesis |
Irina Larina |
R01HL120140 |
|
Neurovascular Regeneration |
Mary Dickinson |
BRPR01EB016629 |
|
A Nuclear Receptor COUP-TFII in Vascular Function: Angiogenesis and Tumorigenesis |
Sophia Tsai |
R01HL076448 |
|
Nuclear Orphan Receptor, COUP-TFII, in Energy Metabolism and Disease |
Sophia Tsai |
R01HL114539 |
|
Regulation of Hematopoietic Progenitors by de novo DNA Methylation |
Peggy Goodell |
R01DK092883 |
|
Human Embryonic Stem Cell Training and Culture Core |
Peggy Goodell |
P01GM081627 |
|
Mechanical Regulation of Vessel Remodeling and Angiogenesis |
Mary Dickinson |
NA |
|
Hippo Signaling in Cardiac Regeneration |
James Martin |
NA |
|
Genome-Wide Association Study for Hypoplastic Left Heart and Related Defects |
John Belmont |
R01HL090506 |
|
Molecular Pathogenesis of Myotonic Dystrophy |
Thomas Cooper |
R01AR045653 |
|
The Role of RERE in Congenital Cardiac Anomalies |
Daryl Scott |
NA |
|
Functional Characterization of Nexilin Mutations Associated with Hypertrophic and Dilated Cardiomyopathy Using Knock-In Mouse Models |
Yuxin Fan |
NA |
Research Faculty
Carolyn Altman, M.D. - Pediatric echocardiography
Dean Andropoulos, M.D. - Brain protection for infant cardiac surgery
Ayse Akcan Arikan, M.D. - Pediatric critical care
Rahul Baijal, M.D. - Pediatric Anesthesiology
Manish Bansal, M.D. - Pediatric cardiology Judith Becker, M.D. fetal Left Heart Hypoplasia
John Belmont, M.D. - CV genetics, cardiovascular malformations and connective tissue disorders
Kenneth Brady, M.D. - Prevention of neurologic injury in children with CV disease
Thomas Cooper, M.D. - Alternative splicing in cardiac development and disease
William Dryer, M.D. - New heart failure therapies, management of HLA sensitized patients before/after transplant
Blaine Easley, M.D. - New methods for monitoring and management of children with heart disease
Yuxin Fan, M.D., Ph.D. - Diagnostic tests for acquired and genetic cardiac diseases, viral myocarditis
Peggy Goodell, M.D. - Hematopoietic stem cells, epigenetic modifications
Amir Jeewa, M.D. - Pediatric heart transplantation, cardiomyopathies, mechanical circulatory support
Leda Kloudas, Ph.D. - Pediatric congenital heart disease
William Kyle, M.D. - Outpatient cardiology
Scott LeMaire, M.D. - Basic and clinical research on aortic disease and aortic wall degeneration
George Mallory, M.D. - Pulmonary hypertension and lung transplantation
James Martin, M.D., Ph.D. - Hippo, Wnt, Bmp signaling in development, regeneration, heart disease
Christina Miyake, MS, M.D. - Inherited cardiac arrhythmia syndromes
Brady Moffett, Phar, M.D., MPH - Clinical pediatrics
Shaine Morris, M.D., MPH - Advanced imaging techniques for genetically-triggered aortopathies
Emad Mossad, M.D. - Neuromonitoring during repair of congenital heart disease
Dhaval Parekh, M.D. - Pediatric cardiology, pediatric/adult congenital heart disease
Ricardo Pignatelli, M.D. - Echocardiography, pediatric cardiomyopathy, ultrasound-targeted microbubbles, Duchenne muscular dystrophy
Fadel Ruiz, M.D. - Pediatric pulmonary hypertension, cystic fibrosis
Craig Rusin, Ph.D. - Physiological signal processing and algorithm development
Daryl Scott, M.D., Ph.D. - Genetics of congenital diaphragmatic hernia, esophageal atresia, cardiomyopathies
Lara Shekerdemian, M.D. - Cardiovascular physiology and mechanical cardiopulmonary support
Amy Sims, M.D. - Pediatric HIV cardiovascular complications
Jesus Vallejo, M.D. - TLR3/TLR4 in acute myocarditis, signal transduction pathways
Eric Williams, M.D. - Pediatric septic shock and stroke
